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NS8593 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS8593 hydrochloride图片
CAS NO:875755-24-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NS8593 HCl
产品介绍
NS8593 hydrochloride 是选择性的SK通道抑制剂。它可逆抑制SK3介导的电流,Kd值为 77 nM。它抑制所有SK1-3亚型的 Ca2+依赖性 (在 0.5 μM Ca2+时,Kd分别为 0.42、0.60 和 0.73 μM),并且不影响中间电导和大电导的钙激活钾通道。

产品描述

NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .

体外活性

It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593.

体内活性

NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1].

Cas No.

875755-24-1

分子式

C17H18ClN3

分子量

299.8

别名

NS8593 HCl

储存和溶解度

DMSO:80 mg/mL (266.84 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years