VU0810464 是一种选择性的非尿素蛋白门控的内向整流钾通道激活剂。 VU0810464对神经元 GIRK1/2和GIRK1/4 的EC50分别为165 nM和720 nM。VU0810464具有脑部渗透性。

VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.

Reduced stress‐induced hyperthermia (SIH), a physiological test of anxiolytic efficacy in wild mice, but had no impact in and Kcnj3 (Girk1) ?/? mice.

Animal Model:Male C57BL/6J mice, Kcnj3?/? siblings female and male C57BL/6J mice. Dosage:10 mg/kg; 30mg/kg. Administration:Intraperitoneal injection

2126040-21-7

C18H21ClFN3O

349.83

DMSO:250 mg/mL (714.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years