ICA-069673是一种KCNQ2/Q3钾通道激活剂，IC50值为0.69 μM。

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50>30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.

582323-16-8

C11H6ClF2N3O

269.64

ICA069673

DMSO:34 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years