BTB06584 是选择性依赖 IF1 的线粒体F1Fo-ATPase抑制剂，可延迟缺血性细胞死亡。

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).

BTB06584使斑马鱼pinotage(pnt)突变体中有缺陷的血红蛋白合成恢复,无明显毒性.

BTB06584以IF1依赖的方式抑制F1 Fo-ATP酶活性,不影响ATP合成,并且还限制由线粒体F1Fo-ATP合酶逆转导致的缺血诱导的损伤。

219793-45-0

C19H12ClNO6S

417.82

H2O:<1 mgml
Ethanol:<1 mgml
DMSO:78 mg/mL (186.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years