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Pyr3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyr3图片
CAS NO:1160514-60-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Pyr3 是一种选择性瞬时受体电位经典通道 3 抑制剂。 Pyr3 以剂量依赖性方式抑制 TRPC3 介导的 Ca2+ 内流 (IC50 = 700 nM)。

产品描述

Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

体外活性

Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner[1].

Cas No.

1160514-60-2

分子式

C16H11Cl3F3N3O3

分子量

456.63

储存和溶解度

DMSO:100 mg/mL (219 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years