MK6-83 是有效的TRPML1的候选激动剂，具有优越的活性。它在IV 型粘脂病中具有研究的价值。

MK6-83 is the transient receptor potential channel ML3 agonist.

MK6-83(0.2-30 μM) shows no signs of cytotoxicity[1]. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts[1].

1062271-24-2

C16H20N2O2S2

336.47

MK683

DMSO:22.5 mg/mL (66.87 mM),Need ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years