您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > M8-B Hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
M8-B Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M8-B Hydrochloride图片
CAS NO:883976-12-3
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
M8-B Hydrochloride 是一种选择性瞬时受体电位 melaSTATin-8 (TRPM8) 通道拮抗剂。

产品描述

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.

体内活性

M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

动物实验

Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1].

Cas No.

883976-12-3

分子式

C22H25ClN2O3S

分子量

432.96

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years