HC067047 Hydrochloride(883031-03-6 free base) 是一种有效的选择性 TRPV4 拮抗剂。它可逆地抑制通过人类、大鼠和小鼠 TRPV4 直系同源物的电流，IC50 值分别为 486 nM、133nM 和 17 nM。

HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.

TRPV4 is a hyperglycemia-related factor that can inhibit cell proliferation and promote cell apoptosis by activating the MAPK signaling pathway in HEI-OC1 cells[1].

HC-067047 increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis[2].

1481646-76-7

C26H29ClF3N3O2

507.98

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years