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SB 452533
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 452533图片
CAS NO:459429-39-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
SB 452533 是TRPV1的选择性拮抗剂,pKb为 7.8。

产品描述

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).

体外活性

SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2[1].

体内活性

Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P<0.05 or P<0.01)and the expression of α-SMA and Vimentin were decreased (P<0.05 or P<0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P<0.05 or P<0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P<0.05 or P<0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533[2].

Cas No.

459429-39-1

分子式

C18H22BrN3O

分子量

376.29

储存和溶解度

Ethanol:<1 mgml
DMSO:50 mg/ml(132.876 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years