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T807
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
T807图片
CAS NO:1415379-56-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AV-1451
产品介绍
T807 是新型的tau正电子发射断层扫描示踪剂。

产品描述

T807 is a novel tracer of tau positron emission tomography (PET).

体外活性

In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques[1]. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified[2].

体内活性

[18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan[1].

Cas No.

1415379-56-4

分子式

C16H10FN3

分子量

263.27

别名

AV-1451

储存和溶解度

DMSO:16.6 mg/mL (63.05 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years