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Tubulin inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tubulin inhibitor 1图片
CAS NO:2237054-53-2
包装:100 mg
市场价:7617元

产品介绍

产品描述

Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.

体外活性

Tubulin inhibitor 1 is an inhibitor of tubulin.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells(IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively). Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.

体内活性

In Balb/c nude mice bearing SK-OV-3 cells, Tubulin inhibitor 1 (50 mg/kg, i.p., )treatment every two days three times for 20-25 days is well tolerated, significantly reduces tumour growth .

Cas No.

2237054-53-2

分子式

C21H24N2O4

分子量

368.43

储存和溶解度

DMSO:125 mg/mL (339.28 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years