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Pironetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pironetin图片
CAS NO:151519-02-7
包装:1 mg
市场价:25167元

产品介绍

产品描述

Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.

体外活性

Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780, and K-NRK cells) treatment suppresses cell proliferation. Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells. The IC50 values against these cell lines are almost 10 ng/mL[1].

体内活性

Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment displays a moderate antitumor effect. However, a severe weight loss is observed as a side effect[1].

Cas No.

151519-02-7

分子式

C19H32O4

分子量

324.46

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years