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Tasidotin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tasidotin hydrochloride图片
CAS NO:623174-20-9
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
ILX651
产品介绍

产品描述

Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics.

体外活性

The greatest difference in sensitivity to Tasidotin is between the more sensitive MDA-MB-435 line and the less sensitive HS 578-T line of the remaining lines. The IC50 values in the two lines are 4 and 200 nM, respectively. The IC50 in Ewing's sarcoma, rhabdomyosarcoma, osteosarcoma, and synovial sarcoma lines ranges from 2 to 320 nM. Tasidotin induces a G2-M arrest that persists for 48 h after Tasidotin is washed from the cells in the SK-ES1 and RH30 cell lines. In vitro, more than half the cells are in the early or late phase of apoptosis 48 h after treatment with Tasidotin. Following treatment for 24 h with 160 nM Tasidotin, the RH30 line, and SK-ES1 line each shows an accumulation of cells in the G2-M phase. At hour 24, nearly all the RH30 cells are in the G2-M phase [1][2].

体内活性

Tasidotin (90 mg/kg/d, mice) treatment has a mean weight loss of<16% following each 5-day treatment of Tasidotin. In vivo, a significant increase in apoptotic nuclei is apparent in xenograft tumors harvested within 24 h after a 5-day course of Tasidotin. Mice treated with 100 mg/kg have a mean weight loss of >20% with no return to their baseline starting weight, and one mouse dies before the second treatment course [2].

Cas No.

623174-20-9

分子式

C32H59ClN6O5

分子量

643.3

别名

ILX651

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years