Optovin 是可逆的光活化TRPA1配体,可实现光介导的神经元兴奋。它通过与氧化还原敏感的半胱氨酸残基产生结构依赖性光化学反应激活 TRPA1。
产品描述
Optovin is a TRPA1 activator, which is reversibly photoactivated.
体外活性
Optovin activates human TRPA1 via structure dependent photochemical reactions. [1]
体内活性
Optovin enables real-time optical control of neurons, and also elicits nociceptive behaviors in adult mice. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. [1]
Cas No.
348575-88-2
分子式
C15H13N3OS2
分子量
315.41
储存和溶解度
DMSO:59 mg/mL (187.1 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years