您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Litronesib
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Litronesib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Litronesib图片
CAS NO:910634-41-2
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
LY-2523355
KF-89617
产品介绍

产品描述

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

体外活性

Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1].

体内活性

Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].

Cas No.

910634-41-2

分子式

C23H37N5O4S2

分子量

511.7

别名

LY-2523355;KF-89617

储存和溶解度

DMSO:50 mg/mL (97.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years