Pyridoxal phosphate 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。

Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost.

54-47-7

C8H10NO6P

247.14

PLP;Vitamin B6 phosphate;Pyridoxal 5′-phosphate;PAL-P;Pyridoxyl phosphate;pyridoxal 5'-phosphate;磷酸吡哆醛

DMSO:40.5 mM
H2O:20.23mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years