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Amikacin disulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amikacin disulfate图片
CAS NO:39831-55-5
包装:100 mg
市场价:468元

产品名称
阿米卡星硫酸盐
BAY-416651 sulfate
Pierami
硫酸阿米卡星
Amikacin sulfate
BB-K8
产品介绍
Amikacin disulfate是氨基糖苷类抗生素,也是卡那霉素的半合成类似物。它具有杀菌作用,直接作用于 30S 和 50S 细菌核糖体亚基,可抑制蛋白质合成。它对大多数革兰氏阴性细菌都有效。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。

产品描述

Amikacin sulfate(BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

体外活性

Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6]

体内活性

Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8]

Cas No.

39831-55-5

分子式

C22H43N5O13·2H2O4S

分子量

781.76

别名

阿米卡星硫酸盐;BAY-416651 sulfate;Pierami;硫酸阿米卡星;Amikacin sulfate;BB-K8

储存和溶解度

H2O:10 mM
DMSO:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years