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Bemnifosbuvir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bemnifosbuvir图片
CAS NO:1998705-64-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AT-511
产品介绍
Bemnifosbuvir 是一种口服活性抑制剂,抑制HCV病毒复制,具有全基因型抗病毒活性。它有效抑制SARS-CoV-2 (COVID-19)感染 (EC90=0.47 μM)。

产品描述

Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.

体外活性

AT-511 is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV[1].In the absence of cells, AT-511 was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM AT-511 and, except in mouse hepatocytes,far exceeded intracellular AT-511 concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey.

体内活性

Treatment with moxifloxacin every 8?hr was accompanied by longer survival than in any other group.Tissue cultures 30?hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers[2].

Cas No.

1998705-64-8

分子式

C24H33FN7O7P

分子量

581.53

别名

AT-511

储存和溶解度

DMSO:95 mg/mL (163.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years