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Favipiravir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Favipiravir图片
CAS NO:259793-96-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
T-705
法匹拉韦
6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
法维拉韦
产品介绍
Favipiravir 是一种有效且选择性的 RNA 依赖性 RNA 聚合酶抑制剂,用于治疗流感病毒感染。

产品描述

Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

体外活性

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]

体内活性

In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]

细胞实验

The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)

Cas No.

259793-96-9

分子式

C5H4FN3O2

分子量

157.104

别名

T-705;法匹拉韦;6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide;法维拉韦

储存和溶解度

Ethanol:12 mg/mL(76.4 mM)
H2O:5 mg/mL (31.82 mM)
DMSO:29 mg/mL (184.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years