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Ledipasvir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ledipasvir图片
CAS NO:1256388-51-8
包装:10 mg
市场价:1668元

产品名称
GS-5885
雷迪帕韦
产品介绍
Ledipasvir 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。

产品描述

Ledipasvir is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

体外活性

Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].

体内活性

Ledipasvir is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey as well as low predicted clearance in human. The pharmacokinetics of Ledipasvir is measured in rats and dogs. Ledipasvir exhibits good half-lives (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume[1].

Cas No.

1256388-51-8

分子式

C49H54F2N8O6

分子量

889.02

别名

GS-5885;雷迪帕韦

储存和溶解度

DMSO:93 mg/mL (104.6 mM)
H2O:<1 mgml
Ethanol:93 mg/mL (104.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years