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Mavorixafor trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mavorixafor trihydrochloride图片
CAS NO:2309699-17-8
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
AMD-070 trihydrochloride
产品介绍

产品描述

Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).

体外活性

Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [1]. Mavorixafor (6.6 μM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells [2].

体内活性

Mavorixafor (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice and lowers the expression of human Alu DNA in mice without body weight loss [2].

Cas No.

2309699-17-8

分子式

C21H30Cl3N5

分子量

458.86

别名

AMD-070 trihydrochloride

储存和溶解度

DMSO:6 mg/mL (13.08 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years