Tetracycline hydrochloride是一种广谱抗生素，抑制多种革兰氏阳性和革兰氏阴性细菌。

Tetracycline Hydrochloride is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry.

Tetracyclines are broad-spectrum agents with activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites. Tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-tetracycline coordination complexes [1].

The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. Under some circumstances, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, the antibiotics are added directly to feed or water or can be administered in aerosols. Tetracyclines could be used for growth promotion or growth enhancement. Tetracyclines are used in aquaculture to control infections in salmon, catfish, and lobsters[2].

64-75-5

C22H25ClN2O8

480.9

Tetracycline HCl;NCI-c55561;盐酸四环素

DMSO:89 mg/mL (185.1 mM)
Ethanol:<1 mgml
H2O:88 mg/mL (183 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years