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Daclatasvir dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Daclatasvir dihydrochloride图片
CAS NO:1009119-65-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
BMS-790052 dihydrochloride
盐酸达拉他韦
产品介绍
Daclatasvir dihydrochloride是是有机阴离子转运多肽 1B (OATP1B) 和OATP1B3抑制剂,IC50分别为 1.5 μM 和 3.27 μM。它也具有口服活性的HCV NS5A蛋白抑制剂,多种HCV复制子基因型的EC50范围为 9-146 pM。

产品描述

Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has yet to be convincingly implicated in cases of clinically apparent liver injury with jaundice.

激酶实验

CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792-928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and Palbociclib (0.001-0.1 μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25°C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4°C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.

Cas No.

1009119-65-6

分子式

C40H52Cl2N8O6

分子量

811.81

别名

BMS-790052 dihydrochloride;盐酸达拉他韦

储存和溶解度

DMSO:56 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years