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TMC647055 Choline Hydroxide Salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TMC647055 Choline Hydroxide Salt图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)
产品介绍
TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂,可用于治疗 HCV 感染。它具有纳摩尔级细胞效力(EC(50) 为 82 nM),相关细胞毒性最小(CC(50)>20 μM),在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。

产品描述

TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.

Cas No.

T21537L

分子式

C37H53N5O8S

分子量

727.91

别名

TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

储存和溶解度

DMSO:60 mg/ml (82.43 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years