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Mericitabine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mericitabine图片
CAS NO:940908-79-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
PSI 6130 diisobutyrate
R-7128
RG 7128
产品介绍
Mericitabine是一种核苷HCV NS5B 聚合酶抑制剂。它充当 RNA 链终止子并防止 RNA 转录物在复制过程中延伸。

产品描述

Mericitabine is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication.

体外活性

PSI-6130 is converted through phosphorylation by cellular kinases to an active 5′-triphosphate metabolite, which inhibits the NS5B RNA polymerase of HCV. Mericitabine is an oral cytidine nucleoside analog prodrug that exhibits strong antiviral effectiveness against the HCV polymerase across all HCV genotypes. Mericitabine is a first-in-class nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphorylation to two active triphosphates. Mericitabine, a cytidine analogue, is an oral prodrug of PSI-6130. PSI-6130 has an EC90 value of 4.6±2 μM in the HCV replicon assay. Mericitabine displays high specificity for HCV, minimal cytotoxicity, and does not affect mitochondrial DNA. Mericitabine shows a relatively good safety profile and significant potency against HCV-1 [2][3].

Cas No.

940908-79-2

分子式

C18H26FN3O6

分子量

399.41

别名

PSI 6130 diisobutyrate;R-7128;RG 7128

储存和溶解度

DMSO:100 mg/mL (250.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years