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RO-9187
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RO-9187图片
CAS NO:876708-03-1
包装:50 mg
市场价:11320元

产品介绍

产品描述

RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

体外活性

RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1].

体内活性

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of RO-9187 (1.4 and 26 μM ) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with RO-9187 (2000 mg/kg/day)[1].

Cas No.

876708-03-1

分子式

C9H12N6O5

分子量

284.23

储存和溶解度

H2O:7.14 mg/mL (25.12 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years