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Hexestrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hexestrol图片
CAS NO:84-16-2
包装与价格:
包装价格(元)
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Bibenzyl
meso-Hexestrol
Hexanoestrol
Hexestrofen
4,4'-(1,2-二乙基亚乙基)二苯酚
产品介绍
Hexestrol 是非甾体合成雌激素,对雌激素受体ERα和ERβ的Ki=均为 0.06 nM。它可增加牛的体重,也可用于雌激素缺乏引起的疾病的研究。

产品描述

Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

体外活性

Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]

体内活性

Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]

Cas No.

84-16-2

分子式

C18H22O2

分子量

270.372

别名

Bibenzyl;meso-Hexestrol;Hexanoestrol;Hexestrofen;4,4'-(1,2-二乙基亚乙基)二苯酚

储存和溶解度

DMSO:39 mg/mL (144.2 mM)
H2O:<1 mgml
Ethanol:39 mg/mL (144.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years