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(E/Z)-4-Hydroxytamoxifen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E/Z)-4-Hydroxytamoxifen图片
CAS NO:68392-35-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(E/Z)-4-羟基他莫昔芬
4-羟基他莫昔芬
Afimoxifene
4-Hydroxytamoxifen
产品介绍
4-Hydroxytamoxifen 是 tamoxifen 的活性代谢物和选择性雌激素受体(ER)调节剂,广泛用于乳腺癌的治疗和化学预防治疗。

产品描述

4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

体外活性

4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants

细胞实验

Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.

动物实验

Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration

Cas No.

68392-35-8

分子式

C26H29NO2

分子量

387.523

别名

(E/Z)-4-羟基他莫昔芬;4-羟基他莫昔芬;Afimoxifene;4-Hydroxytamoxifen

储存和溶解度

DMSO:71 mg/mL (183.2 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years