Propyl pyrazole triol 是雌激素受体 α(ERα)选择性激动剂。它对 ERα 的相对结合亲和力 (ERα: 49%) 比雌激素受体 β (ERβ: 0.12%) 高 410 倍。

Propyl pyrazole triol is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

In ERα-U2OS-Luc cells, the EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM[1].

263717-53-9

C24H22N2O3

386.44

PPT

DMSO:99 mg/mL (256.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years