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NXT629
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NXT629图片
CAS NO:1454925-59-7
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

体外活性

NXT629 is a potent and selective antagonist of PPAR-α(human PPARα,IC50 of 77 nM), shows high selectivity over other nuclear hormone receptor, [2].

体内活性

NXT629 has poor oral bioavailability in mice and rats.?NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice.?NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis.?NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung[2].

Cas No.

1454925-59-7

分子式

C35H39N5O3S

分子量

609.78

储存和溶解度

DMSO:125 mg/mL (204.99 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years