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Prinaberel
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prinaberel图片
CAS NO:524684-52-4
包装:100 mg
市场价:7241元

产品名称
ERB 041
普林贝瑞
产品介绍

产品描述

Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.

体外活性

Treatment with ERβ selective estrogen agonists liquiritigenin and ERB-041 reduced the ability to invade a reconstituted basement membrane and to migrate in response to the cellular stimulus [1]. Pretreatment the PMs with ERB-041 resulted in significant inhibition of LPS-induced iNOS expression and NF-kappaB activation by preventing its nuclear translocation [3].

体内活性

Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041-treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by a decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis [2].

Cas No.

524684-52-4

分子式

C15H10FNO3

分子量

271.24

别名

ERB 041;普林贝瑞

储存和溶解度

DMSO:38 mg/mL (140.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years