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ACP-105
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACP-105图片
CAS NO:899821-23-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ACP-105 是选择性的、可口服的雄激素受体调节剂 , 能够作用于野生型 AR (pEC50:9.0)和 T877A 突变型 AR (pEC50:9.3)。

产品描述

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

体外活性

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h[1].

体内活性

Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance[2].

Cas No.

899821-23-9

分子式

C16H19ClN2O

分子量

290.79

储存和溶解度

DMSO:60 mg/mL (206.33 mM)
Ethanol:60 mg/mL(206.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years