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S-23
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-23图片
CAS NO:1010396-29-8
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
S23
产品介绍
S-23 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。

产品描述

S-23 is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

体外活性

Administration of 10 nM S-23 induces AR-mediated transcriptional activation in CV-1 cells [2].

体内活性

Administration of S-23 to castrated animals increases the weights of the androgen-dependent organ dose-dependently with the ED50s of S-23 in the prostate and levator ani muscle of 0.43 and 0.079 mg/d, respectively[2].

Cas No.

1010396-29-8

分子式

C18H13ClF4N2O3

分子量

416.75

别名

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;S23

储存和溶解度

DMSO:88 mg/mL (211.16 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years