您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Cyproterone Acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cyproterone Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyproterone Acetate图片
CAS NO:427-51-0
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Androcur
Cyproterone 17-O-acetate
醋酸环丙孕酮
醋酸环丙氯地孕酮
产品介绍
Cyproterone acetate 是能够抗雄激素 (IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。

产品描述

Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.

体外活性

经Cyproterone acetate处理后,大鼠体内GST和超氧化物歧化酶活性显著降低,NO明显提高,MDA含量显著增加,反映了大鼠睾丸的氧化状态.Cyproterone acetate对生殖器官重量有直接的不良作用,且会使精子数量和 Ca2+含量显著降低.秋季人为的光照时长增加以及CA处理对精子运动及形态存在负面影响. 以Cyproterone acetate处理雄激素受体后,睾丸中精细胞鱼精蛋白水平会首先下降,核染色质浓缩过程涉及的精子水平也会下降.

体内活性

在睾丸激素(10 nM)存在时,低浓度Cyproterone acetate对T-刺激的3XHRE-LUC转录具有抑制作用,高浓度作用则相反。Cyproterone acetate既有明显的拮抗性能亦有部分激活剂特性,相对浓度较高时可激活AR(EC50为4.0 μM)。

Cas No.

427-51-0

分子式

C24H29ClO4

分子量

416.94

别名

Androcur;Cyproterone 17-O-acetate;醋酸环丙孕酮;醋酸环丙氯地孕酮

储存和溶解度

H2O:<1 mgml
DMSO:77 mg/mL (184.7 mM)
Ethanol:10 mg/mL (23.98 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years