您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > YK11
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
YK11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YK11图片
CAS NO:1370003-76-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(17ALPHA,20E)-17,20-[(1-甲氧基乙亚基)二(氧基)]-3-氧代-19-去甲孕甾-4,20-二烯-21-羧酸甲酯
产品介绍
YK11 是雄激素受体部分激动剂,当使用浓度为 0.1 μM 时,可激活过表达雄激素受体的 HEK293 细胞中的雄激素受体转录活性,具有成骨活性。

产品描述

YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.

体外活性

The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. Suggest that the induction of Fst is important for the anabolic effect of YK11[1].

Cas No.

1370003-76-1

分子式

C25H34O6

分子量

430.541

别名

(17ALPHA,20E)-17,20-[(1-甲氧基乙亚基)二(氧基)]-3-氧代-19-去甲孕甾-4,20-二烯-21-羧酸甲酯

储存和溶解度

DMSO:64 mg/mL (148.65 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years