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LY341495
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY341495图片
CAS NO:201943-63-7
包装:50 mg
市场价:8591元

产品介绍

产品描述

LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).

体内活性

LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 (3.0 mg/kg) reduces Dvl-2, pGSK-3α/β, and β-catenin protein levels but Dvl-1, Dvl-3, and GSK-3α/β are unaffected in both the PFC and STR. LY341495 (0.3, 1, and 3 mg/kg, i.p.) shows a lower level of discrimination in rats[1]. LY341495 has generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268[2]. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice[3].

Cas No.

201943-63-7

分子式

C20H19NO5

分子量

353.37

储存和溶解度

DMSO:6 mg/mL (16.98 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years