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Protirelin Acetate(24305-27-9 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protirelin Acetate(24305-27-9 free base)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议

产品名称
TRH Acetate
Lopremone Acetate
Synthetic thyrotropin-releasing hormone Acetate
Thyroliberin Acetate
TRF Acetate
pGlu-His-Pro-NH2 Acetate
产品介绍
Protirelin Acetate(24305-27-9 free base) 是一种三肽,可刺激促甲状腺素和催乳素的释放。

产品描述

Protirelin Acetate is a tripeptide that stimulates the release of thyrotropin and prolactin.

体内活性

Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin

动物实验

Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.

Cas No.

T6956L

分子式

C18H26N6O6

分子量

422.44

别名

TRH Acetate;Lopremone Acetate;Synthetic thyrotropin-releasing hormone Acetate;Thyroliberin Acetate;TRF Acetate;pGlu-His-Pro-NH2 Acetate

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years