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L-Thyroxine sodium salt pentahydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Thyroxine sodium salt pentahydrate图片
CAS NO:6106-07-6
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
左旋甲状腺素钠五水合物
Sodium levothyroxine pentahydrate
L-甲状腺素钠五水合物
Levothyroxine
产品介绍
L-Thyroxine sodium salt pentahydrate 是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。

产品描述

L-Thyroxine sodium salt pentahydrate is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

体内活性

L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps, and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. Deiodinases, which catalyze the conversion of thyroxine (pro-hormone) to the active thyroid hormone, is associated with thyroid-stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze the activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play a pivotal role in the negative feedback regulation of pituitary TSH secretion [1]. A significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with a standard diet (p<0.001), in rats fed 12 weeks with the iodine-free diet. An increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19), in the group treated with low doses of L-Thyroxine. Rats treated with high doses of L-Thyroxine show a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03) [2].

Cas No.

6106-07-6

分子式

C15H20I4NNaO9

分子量

888.93

别名

左旋甲状腺素钠五水合物;Sodium levothyroxine pentahydrate;L-甲状腺素钠五水合物;Levothyroxine

储存和溶解度

DMSO:28 mg/mL (31.50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years