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TUG-891
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TUG-891图片
CAS NO:1374516-07-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
TUG 891
TUG891
产品介绍
TUG891 是一种选择性的长链游离脂肪酸受体 4 (FFA4/GPR120) 的激动剂。

产品描述

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

体外活性

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].

激酶实验

Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].

Cas No.

1374516-07-0

分子式

C23H21FO3

分子量

364.416

别名

TUG 891;TUG891

储存和溶解度

DMSO:36.4 mg/mL(100 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years