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AMG 837 calcium hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AMG 837 calcium hydrate图片
CAS NO:1259389-38-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
AMG 837 calcium hydrate 是口服有效的GPR40/FFA1部分激动剂,抑制 [3H]AMG 837 与人类FFA1受体的特异性结合,pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。

产品描述

AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 >10,000 nM).

体外活性

GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50: 13 nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50s: 23/13 nM). AMG 837 was a partial agonist on GPR40 with maximal activity 85% of that shown by DHA. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50: 3 μM) on the α2-adrenergic receptor [1].

体内活性

In rats, AMG 837 increases insulin release when glucose levels are elevated [2].

Cas No.

1259389-38-2

分子式

C26H23F3O4·1/2Ca

分子量

476.5

储存和溶解度

DMSO:40 mg/mL (87.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years