CAY10786 是 G 蛋白偶联受体 52 (GPR52, IC50 = 0.63 μM) 的拮抗剂。

CAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).

CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons[1].

In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT[1].

1239987-91-7

C15H14OS

242.34

GPR52 antagonist-1

DMSO:245 mg/mL (1010.98 mM),Need ultrasonic
Chloroform:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years