LY2922470 是选择性口服有效的GPR40激动剂，作用于 人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平，同时显著增加胰岛素和 GLP-1，有潜力用于 2 型糖尿病的研究。

LY2922470 is a potent, selective G protein-coupled receptor 40 (GPR40) agonist, with EC50s of 7 nM for human GPR40, 1 nM for mouse GPR40 and 3 nM for rat GPR40, respectively. LY2922470 reduces glucose levels along and increases insulin and GLP-1 significantly.

1423018-12-5

C28H29NO4S

475.6

DMSO:125 mg/mL (262.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years