Desonide是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。

Desonide is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release of arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

638-94-8

C24H32O6

416.514

Prednacinolone;地索奈德;Locapred;Tridesilon

H2O:<1 mgml
Ethanol:28 mg/mL (67.2 mM)
DMSO:77 mg/mL (184.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years