AZD7594 是非甾体类糖皮质激素受体的选择性调节剂(IC50:0.9 nM)。

AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).

AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, >10 μM).

AZD7594 has anti-inflammatory activity and efficiently inhibits rat lung edema. AZD5423 displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation.

1196509-60-0

C32H32F2N4O6

606.62

AZD7594;AZ13189620

DMSO:79 mg/mL (130.23 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years