Dexamethasone palmitate (DXP) 是 Dexamethasone 的前药。Dexamethasone 是糖皮质激素受体激动剂。与Dexamethasone相比， DXP对糖皮质激素受体的亲和力低 47 倍。DXP显示出抗炎活性。

Dexamethasone palmitate, a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an anti-inflammatory agent.

In a murine collagen-induced arthritis model, their passive accumulation in arthritic joints leads to disease remission and recovery of the joint structure at a dose of 1 mg/kg dexamethasone, without any adverse effects[1].

14899-36-6

C38H59FO6

630.87

DXP;地塞米松棕榈酸酯

DMSO:250 mg/mL (396.28 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years