Fludrocortisone acetate 是一种合成的盐皮质激素,可减少尿液中钠丢失量,也用于增加血压,有用于阿狄森氏病的研究潜力。
产品描述
Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Cas No.
514-36-3
分子式
C23H31FO6
分子量
422.493
别名
醋酸氟氢可的松;9α-Fluorcortisol acetate;9α-fluorocortisol acetate;9α-Fludrocortisone acetate
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years