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TNF Protease Inhibitor 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TNF Protease Inhibitor 2图片
CAS NO:187034-31-7
包装:10 mg
市场价:8517元

产品名称
TAPI-2
产品介绍

产品描述

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

体外活性

TAPI-2 bounds to h-meprin with IC50 20 μM for h-meprin β subunit and 1.5 nM for h-meprin α subunit. Generally, h-meprin α is inhibited more strongly than the β subunit [1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5–40 μM) [2].

Cas No.

187034-31-7

分子式

C19H37N5O5

分子量

415.53

别名

TAPI-2

储存和溶解度

DMSO:20 mg/mL (48.13 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years