UNC569 是一种ATP 竞争性的、可逆、具有口服活性的Mer激酶抑制剂，其IC50=2.9 nM，Ki=4.3 nM。它还抑制Axl和Tyro3，IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。

Lesinurad is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. Lesinurad could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.

1350547-65-7

C22H29FN6

396.5

UNC 569

H2O:Insoluble
DMSO:30 mg/mL (75.66mM),Need ultrasonic
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years