AZ7550 hydrochloride 是 AZD9291 的活性代谢物，可抑制IGF1R活性，IC50为 1.6 μM。

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).

2309762-40-9

C27H32ClN7O2

522.04

AZ7550 hydrochloride (1421373-99-0 free base)

DMSO:1.5 mg/mL (2.8 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years