CH7057288 是选择性TRK抑制剂。
产品描述
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
体外活性
CH7057288, a potent and selective TRK inhibitor belonging to a novel chemical class.CH7057288 induced regression of intracranial tumors and greatly improved event-free survival in an intracranial implantation model mimicking brain metastasis.
Cas No.
2095616-82-1
分子式
C32H31N3O5S
分子量
569.68
储存和溶解度
DMSO:34 mg/mL (59.68 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years